Yeast life-span extension by calorie restriction is independent of NAD fluctuation

被引：124
|
作者：
Anderson, RM
Latorre-Esteves, M
Neves, AR
Lavu, S
Medvedik, O
Taylor, C
Howitz, KT
Santos, H
Sinclair, DA
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Univ Nova Lisboa, Inst Tecnol Quim & Biol, P-2780156 Oeiras, Portugal
[3] Biomol Res Labs Inc, Plymouth Meeting, PA 19462 USA
来源：
SCIENCE | 2003年 / 302卷 / 5653期
关键词：
D O I：
10.1126/science.1088697
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD(+)-dependent deacetylase. We report that CR reduces nuclear NAD(+) levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD(+): NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.
引用
收藏
页码：2124 / 2126
页数：3
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