IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma

被引：47

作者：

Barrio, Santiago ^{[1
]}

Munawar, Umair ^{[2
]}

Zhu, Yuan Xiao ^{[3
]}

Giesen, Nicola ^{[4
]}

Shi, Chang-Xin ^{[3
]}

Da Via, Matteo ^{[1
]}

Sanchez, Ricardo ^{[6
]}

Bruins, Laura ^{[3
]}

Demler, Theresa ^{[2
]}

Mueller, Nicole ^{[1
,5
]}

Haertle, Larissa ^{[1
]}

Garitano, Andoni ^{[1
]}

Steinbrunn, Torsten ^{[1
]}

Danhof, Sophia ^{[1
]}

Cuenca, Isabel ^{[6
]}

Barrio-Garcia, Clara ^{[7
]}

Braggio, Esteban ^{[3
]}

Rosenwald, Andreas ^{[8
]}

Martinez-Lopez, Joaquin ^{[6
]}

Rasche, Leo ^{[1
]}

Raab, Marc S. ^{[4
,5
]}

Stewart, A. Keith ^{[3
,9
]}

Einsele, Hermann ^{[1
]}

Stuehmer, Thorsten ^{[2
]}

Kortuem, K. Martin ^{[1
]}

机构：

[1] Univ Hosp Wurzburg, Dept Internal Med 2, Wurzburg, Germany

[2] Univ Hosp Wurzburg, Comprehens Canc Ctr Mainfranken, Wurzburg, Germany

[3] Mayo Clin, Dept Hematol, Scottsdale, AZ USA

[4] Heidelberg Univ Hosp, Dept Internal Med 5, Heidelberg, Germany

[5] German Canc Res Ctr, CCU Mol Hematol Oncol, Heidelberg, Germany

[6] Univ Complutense Madrid, Hematol Dept, CNIO Clin Res Unit H120, Hosp 12 Octubre,CIBERONC, Madrid, Spain

[7] Ludwig Maximilians Univ Munchen, Gene Ctr, Munich, Germany

[8] Univ Wurzburg, Inst Pathol, Wurzburg, Germany

[9] Mayo Clin, Ctr Individualized Med, Rochester, MN USA

来源：

HAEMATOLOGICA | 2020年 / 105卷 / 05期

关键词：

REVEALS;

D O I：

10.3324/haematol.2019.217943

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E237 / E241

页数：5

共 50 条

[1] IKZF1/3 and CRL4CRBN E3 Ubiquitin Ligase Mutations Associate with IMiD Resistance in Relapsed Multiple Myeloma
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[J]. BLOOD, 2017, 130
[2] CRL4CRBN E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma
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[J]. CANCERS, 2022, 14 (18)
[3] New paradigm in drug action: Differentiated gain of function amongst IMiD® analogues binding the E3 ubiquitin ligase, CRL4CRBN
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[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
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[5] A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
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[9] Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN
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