Keeping Tumors Out of the MAPK fitness Zone

被引：12
|
作者：
Stern, David F. [1 ,2 ]
机构：
[1] Yale Sch Med, Dept Pathol, New Haven, CT USA
[2] Yale Sch Med, Yale Canc Ctr, New Haven, CT USA
来源：
CANCER DISCOVERY | 2018年 / 8卷 / 01期
关键词：
ACQUIRED-RESISTANCE; MELANOMA; VEMURAFENIB; EVOLUTION; STRATEGY; PHASE-3;
D O I：
10.1158/2159-8290.CD-17-1243
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Greatest fitness of tumor cell subclones in patients undergoing MAPK-targeting therapies requires just-right levels of MAPK pathway signaling. New therapeutic approaches induce tumor cell death by intensifying MAPK signaling induced by inhibitor withdrawal in combination with DNA damage, or prevent selection of resistant clones with a steep fitness barrier imposed by triple combination of BRAF, MEK, and ERK inhibitors. (C) 2018 AACR.
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页码：20 / 23
页数：4
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