Megathyrin B:: A cytotoxic diterpene from Isodon megathyrsus

被引：5
|
作者：
Qiu, SX
Sun, HD
Lobkovsky, E
Chai, H
Clardy, I
Farnsworth, NR
Pezzuto, JM
Fong, HHS
机构：
[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA
[2] Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
[3] Cornell Univ, Baker Lab, Dept Chem, Ithaca, NY 14853 USA
来源：
PLANTA MEDICA | 1998年 / 64卷 / 08期
关键词：
Isodon megathyrsus; Labiatae; leaves; ent-kaurene diterpene; human cancer lines; cytotoxic activity; 2D-NMR techniques; X-ray crystallography; megathyrin B; electrospray LC/MS;
D O I：
10.1055/s-2006-957567
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
From the leaves of Isodon megothyrsus, a novel entkaurene diterpene, megathyrin B, was isolated and its structure determined as 1 alpha,7 beta,11 beta,15 beta-tetrahydroxy-ent-7 alpha,20-epoxykaur-16-ene by 1D- and 2D-NMR spectral analysis. Additionally, its stereochemistry was unambiguously assigned by X-ray crystallography. This compound was cytotoxic to the KB and KB-V cell lines.
引用
收藏
页码：728 / 731
页数：4
相关论文
共 50 条
  • [1] CYTOTOXIC DITERPENOIDS FROM ISODON MEGATHYRSUS
    SUN, HD
    LIN, ZW
    NIU, FD
    LIN, LZ
    CHAI, HY
    PEZZUTO, JM
    CORDELL, GA
    JOURNAL OF NATURAL PRODUCTS, 1994, 57 (10): : 1424 - 1429
  • [2] Maoecrystal Z, a cytotoxic diterpene from Isodon eriocalyx with a unique skeleton
    Han, Quan-Bin
    Cheung, Susan
    Tai, Joseph
    Qiao, Chun-Feng
    Song, Jing-Zheng
    Tso, Ting-Fai
    Sun, Han-Dong
    Xu, Hong-Xi
    ORGANIC LETTERS, 2006, 8 (21) : 4727 - 4730
  • [3] Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata
    Zhang, HJ
    Fan, ZT
    Tan, GT
    Chai, HB
    Pezzuto, JM
    Sun, HD
    Fong, HHS
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (02): : 215 - 217
  • [4] A New Diterpene Glycoside from Isodon forrestii
    Shuang Xi MEI1
    Chinese Chemical Letters, 2001, (02) : 145 - 146
  • [5] A new diterpene glycoside from Isodon forrestii
    Mei, SX
    Deng, YX
    Han, QB
    Lin, ZW
    Sun, HD
    CHINESE CHEMICAL LETTERS, 2001, 12 (02) : 145 - 146
  • [6] Cytotoxic diterpenoids from Isodon enanderianus
    Xiang, W
    Na, Z
    Li, SH
    Li, ML
    Li, RT
    Tian, QE
    Sun, HD
    PLANTA MEDICA, 2003, 69 (11) : 1031 - 1035
  • [7] A novel diterpene hydroperoxide, glutinosin C, from Isodon glutinosa
    Niu, NM
    Li, SH
    Zhao, QS
    Lin, ZW
    Sun, HD
    Lu, Y
    Zhang, LL
    Zheng, QT
    TETRAHEDRON LETTERS, 2002, 43 (30) : 5277 - 5280
  • [8] CONSTITUTION AND STEREOCHEMISTRY OF ENMEIN A DITERPENE FROM ISODON TRICHOCARPUS KUDO
    KUBOTA, T
    MATSUURA, T
    TSUTSUI, T
    UYEO, S
    IRIE, H
    NUMATA, A
    FUJITA, T
    SUZUKI, T
    TETRAHEDRON, 1966, 22 (05) : 1659 - &
  • [9] A new ent-kaurane diterpene from Isodon henryi
    Jiang, Xue
    Zhang, Ling-Xia
    Feng, Qing-Mei
    Wu, Hong
    Liu, Ya-Lin
    Wang, De-Qin
    Dai, Li-Ping
    Wang, Zhi-Min
    NATURAL PRODUCT RESEARCH, 2021, 35 (14) : 2346 - 2352
  • [10] Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues
    Dai, Jia-Meng
    Yan, Bing-Chao
    Kong, Ling-Mei
    Hu, Kun
    Li, Xing-Ren
    Li, Xiao-Nian
    Sun, Han-Dong
    Li, Yan
    Puno, Pema-Tenzin
    ORGANIC CHEMISTRY FRONTIERS, 2023, 11 (01) : 37 - 46
12345