Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

被引：28
|
作者：
Rungatscher, Alessio [1 ]
Tessari, Maddalena [1 ]
Stranieri, Chiara [2 ]
Solani, Erika [2 ]
Linardi, Daniele [1 ]
Milani, Elisabetta [1 ]
Montresor, Alessio [2 ]
Merigo, Flavia [3 ]
Salvetti, Beatrice [3 ]
Menon, Tiziano [1 ]
Faggian, Giuseppe [1 ]
机构：
[1] Univ Verona, Dept Surg, Div Cardiac Surg, I-37126 Verona, Italy
[2] Univ Verona, Dept Pathol & Diagnost, Sect Gen Pathol, I-37126 Verona, Italy
[3] Univ Verona, Dept Neurol & Movement Sci, I-37126 Verona, Italy
来源：
MEDIATORS OF INFLAMMATION | 2015年 / 2015卷
关键词：
NF-KAPPA-B; CARDIOPULMONARY BYPASS; RAT MODEL; INFLAMMATORY RESPONSE; KINASE PATHWAYS; CARDIAC-ARREST; PHOSPHORYLCHOLINE; NEUTROPHILS;
D O I：
10.1155/2015/484979
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on home-made, nonstandardized, and hardly reproducible oxygenators. The present study has generated fundamental information on the role of oxygenator of ECC in activating inflammatory signaling pathways on leukocytes, leading to systemic inflammatory response, and organ dysfunction. The present results suggest that experimental animal models of ECC used in translational research on inflammatory response should be based on standardized, reproducible oxygenators with clinical characteristics.
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页数：7
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