Recent progress in broadly neutralizing antibodies to HIV

被引：270

作者：

Sok, Devin ^{[1
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Burton, Dennis R. ^{[1
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机构：

[1] Scripps Res Inst, Dept Immunol & Microbiol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, IAVI Neutralizing Antibody Ctr, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA

[4] Int AIDS Vaccine Initiat, New York, NY 10004 USA

[5] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

来源：

NATURE IMMUNOLOGY | 2018年 / 19卷 / 11期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

HUMAN MONOCLONAL-ANTIBODIES; IMMUNODEFICIENCY VIRUS CHALLENGE; MUCOSAL SHIV CHALLENGE; IG KNOCKIN MICE; VACCINE DESIGN; TREATMENT INTERRUPTION; ENVELOPE TRIMER; CD4; BINDING; CELL SPREAD; IN-VIVO;

D O I：

10.1038/s41590-018-0235-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characterization of novel bnAbs, recent data on the effects of bnAbs in vivo in humans and animal models, and the importance of both kinds of data for the application of Abs to prophylaxis and therapy and to guide vaccine design. We seek to place newly discovered bnAbs in the context of existing bnAbs, and we explore the various characteristics of the antibodies that are most desirable for different applications.

引用

页码：1179 / 1188

页数：10

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