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Sequential Sonogashira and Suzuki cross-coupling reactions in the indole and indazole series

被引：38
|
作者：
Witulski, B
Azcon, JR
Alayrac, C
Arnautu, A
Collot, V
Rault, S
机构：
[1] Univ Munster, Inst Organ Chem, D-48143 Munster, Germany
[2] CERMN, UFR Sci Pharmaceut, F-14032 Caen, France
来源：
SYNTHESIS-STUTTGART | 2005年 / 05期
关键词：
palladium; catalysis; alkynes; indoles; indazoles;
D O I：
10.1055/s-2005-861825
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
3-Iodoindoles, 5-bromo-3-iodoindoles and 5-bromo-3-iodoindazoles have been studied with respect to their reactivity and selectivity in palladium catalyzed Sonogashira and Suzuki cross-coupling reactions. As a result, sequential Sonogashira-Sonogashira, Sonogashira-Suzuki, and Suzuki-Sonogashira reactions with 5-bromo-3-iodoindoles or indazoles were used to obtain a large range of new functionalized indoles and indazoles, which are potential 5-HT receptor ligands.
引用
收藏
页码：771 / 780
页数：10
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