Real-time mass sensing by nanomechanical resonators in fluid

被引：13

作者：

Ghatkesar, MK ^{[1
]}

Barwich, V ^{[1
]}

Braun, T ^{[1
]}

Bredekamp, AH ^{[1
]}

Drechsler, U ^{[1
]}

Despont, M ^{[1
]}

Lang, HP ^{[1
]}

Hegner, M ^{[1
]}

Gerber, C ^{[1
]}

机构：

[1] Univ Basel, Inst Phys, CH-4003 Basel, Switzerland

来源：

PROCEEDINGS OF THE IEEE SENSORS 2004, VOLS 1-3 | 2004年

关键词：

cantilever sensor; bio-sensor; mass measurement;

D O I：

10.1109/ICSENS.2004.1426357

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We have developed a sensitive method for real-time mass sensing in a fluid using a microfabricated array of nanomechanical cantilevers actuated at their resonance frequencies. The sensor platform consists of a streptavidin layer immobilised onto gold-coated cantilevers and interacts with biotin-labeled latex beads. The addition of mass involved with this process decreased the resonance frequency. By monitoring frequency spectra of higher harmonies we measured a mass sensitivity of 3.3 Hz/pg. Our data demonstrate that the sensitivity can be increased by operating the cantilever at higher harmonics.

引用

页码：1060 / 1063

页数：4

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