A phase I trial of docetaxel based induction and concomitant chemotherapy in patients with locally advanced head and neck cancer

被引：8
|
作者：
Seiwert, Tanguy Y.
Cohen, Ezra E. W.
Haraf, Daniel J.
Stenson, Kerstin
Blair, Elizabeth A.
Mauer, Ann
Dekker, Allison
Vokes, Everett E.
机构：
[1] Univ Chicago, Hematol Oncol Sect, Canc Res Ctr, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Radiat Oncol, Chicago, IL 60637 USA
[3] Univ Chicago, Dept Surg Otorhinolaryngol, Chicago, IL 60637 USA
来源：
CANCER INVESTIGATION | 2007年 / 25卷 / 06期
关键词：
phase I; locally advanced head and neck cancer; docetaxel; chemoradiotherapy; induction chemotherapy; 5-FU; hydroxyurea;
D O I：
10.1080/07357900701357993
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this study was to determine the maximum tolerated dose (MTD) of docetaxel based induction and concomitant chemoradiotherapy (CRT) after using the FHX platform (5 = 5-FU, H = hydroxyurea, X = Radiation). Patients with Stage III/IV locally advanced HNSCC were enrolled. Induction chemotherapy (carboplatin/docetaxel) was followed by 5 cycles of concomitant docetaxel based CRT. No DLTs were observed in dose levels 1/2 for induction and CRT. Dose level 2 was expanded. The overall survival CR rate after CRT was 79 percent. Median overall (OS) has not been reached and 2-year OS is 80.7 percent. The recommended Phase II dose of docetaxel with FHX CRT is 25 mg/m(2) and 35 mg/m(2) in combination with carboplatin induction (AUC = 6).
引用
收藏
页码：435 / 444
页数：10
相关论文
共 50 条
  • [1] A phase II trial of induction chemotherapy with docetaxel/capecitabine (DC) for patients with locally advanced head and neck cancer
    Yun, Hwan-Jung
    Kim, Jin-Man
    Song, Chang-June
    Park, Seok-Won
    Roh, Jong-Lyel
    Park, Keon-Uk
    Shin, Yousik
    Jo, Deog-Yeon
    Kim, Samyong
    Cho, Moon-June
    ANNALS OF ONCOLOGY, 2004, 15 : 138 - 139
  • [2] Phase I trial of concomitant hyperfractionated radiotherapy with docetaxel and cisplatin for locally advanced head and neck cancer
    Allal, AS
    Zwahlen, D
    Becker, M
    Dulguerov, P
    Mach, N
    CANCER JOURNAL, 2006, 12 (01): : 63 - 68
  • [3] Update of a phase II trial of induction chemotherapy with docetaxel/capecitabine (DC) for patients with locally advanced head and neck cancer
    Yang, Y. J.
    Yun, G. W.
    Lee, I. H.
    Kim, S. M.
    Kim, J. M.
    Yoon, Y. H.
    Koo, B. S.
    Cho, M. J.
    Kim, S. Y.
    Yun, H. J.
    EJC SUPPLEMENTS, 2009, 7 (02): : 492 - 492
  • [4] Multicenter phase I-II trial of docetaxel, cisplatin, and fluorouracil induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck
    Posner, MR
    Glisson, B
    Frenette, G
    Al-Sarraf, M
    Colevas, AD
    Norris, CM
    Seroskie, JD
    Shin, DM
    Olivares, R
    Garay, CA
    JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (04) : 1096 - 1104
  • [5] Phase I trial of concomitant hyperfractionated radiotherapy with docetaxel and cisplatin for locally advanced head and neck carcinomas
    Allal, AS
    Zwahlen, D
    Becker, M
    Dulguerov, P
    Mach, N
    STRAHLENTHERAPIE UND ONKOLOGIE, 2005, 181 : 134 - 134
  • [6] A phase I/II trial of induction chemotherapy followed by concomitant docetaxel with concomitant boost radiotherapy (CBR) for cancer of the head and neck.
    Prellop, P
    Ove, R
    Meredith, R
    Bonner, J
    Peters, G
    Carroll, W
    Spencer, S
    Nabell, L
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 523S - 523S
  • [7] Phase I trial of concomitant hyperfractionated radiotherapy with docetaxel and cisplatin for locally advanced head and neck carcinomas.
    Allal, AS
    Zwahlen, D
    Becker, M
    Dulguerov, P
    Mach, N
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 518S - 518S
  • [8] Induction chemotherapy in head and neck cancer patients followed by concomitant docetaxel-based radiochemotherapy
    Mencoboni, M.
    Grillo-Ruggieri, F.
    Salami, A.
    Scasso, F.
    Rebella, L.
    Grimaldi, A.
    Dellepiane, M.
    Moratti, G.
    Bruzzone, A.
    Spigno, F.
    Ghio, R.
    Figliomeni, M.
    EUROPEAN JOURNAL OF CANCER CARE, 2011, 20 (04) : 503 - 507
  • [9] Induction chemotherapy in locally advanced head and neck cancer
    Shimizu, Yasushi
    Taguchi, Jun
    Kinoshita, Ichiro
    Tsuchiya, Kazuhiko
    Shirato, Hiroki
    Homma, Akihiro
    Fukuda, Satoshi
    Akita, Hirotoshi
    ANNALS OF ONCOLOGY, 2015, 26 : 33 - 33
  • [10] Induction chemotherapy for locally advanced head and neck cancer
    Calais, G.
    Chapet, S.
    Ruffier-Loubiere, A.
    Bernadou, G.
    CANCER RADIOTHERAPIE, 2013, 17 (5-6): : 498 - 501
12345