Combining radiotherapy with immunotherapy: the past, the present and the future

被引：83

作者：

Van Limbergen, Evert J. ^{[1
]}

De Ruysscher, Dirk K. ^{[1
,2
]}

Pimentel, Veronica Olivo ^{[1
]}

Marcus, Damienne ^{[1
]}

Berbee, Maaike ^{[1
]}

Hoeben, Ann ^{[3
]}

Rekers, Nicolle ^{[1
,4
]}

Theys, Jan ^{[1
]}

Yaromina, Ala ^{[1
]}

Dubois, Ludwig J. ^{[1
]}

Lambin, Philippe ^{[1
]}

机构：

[1] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Radiat Oncol MAASTRO, Med Ctr, Maastricht, Netherlands

[2] Katholieke Univ Leuven, Radiat Oncol, Leuven, Belgium

[3] Maastricht Univ, Med Ctr, Dept Internal Med, Div Med Oncol,GROW Sch Oncol & Dev Biol, Maastricht, Netherlands

[4] Tech Univ Denmark, Div Immunol & Vaccinol T Cells & Canc, Natl Vet Inst, Lyngby, Denmark

来源：

BRITISH JOURNAL OF RADIOLOGY | 2017年 / 90卷 / 1076期

基金：

欧盟地平线“2020”;

关键词：

REGULATORY T-CELLS; LOCAL RADIATION; LUNG-CANCER; TUMOR-CELLS; PRECLINICAL RATIONALE; COMPLETE RESPONSE; IMMUNE-RESPONSES; THERAPY; HYPOXIA; IRRADIATION;

D O I：

10.1259/bjr.20170157

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The advent of immunotherapy is currently revolutionizing the field of oncology, where different drugs are used to stimulate different steps in a failing cancer immune response chain. This review gives a basic overview of the immune response against cancer, as well as the historical and current evidence on the interaction of radiotherapy with the immune system and the different forms of immunotherapy. Furthermore the review elaborates on the many open questions on how to exploit this interaction to the full extent in clinical practice.

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页数：9

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