PK/PD target characterization of the novel echinocandin CD101 against Candida spp. in a neutropenic mouse model of disseminated candidiasis

被引:0
|
作者
Sandison, T. [1 ]
Lepak, A. [2 ]
Zhao, M. [2 ]
Vanscoy, B. [3 ]
Ambrose, P. [3 ]
Andes, D. [2 ]
机构
[1] Cidara Therapeut, San Diego, CA USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53706 USA
[3] ICPD, Schenectady, NY USA
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暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
P349
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页码:223 / 224
页数:2
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    Boikov, Dina A.
    Locke, Jeffrey B.
    James, Kenneth D.
    Bartizal, Ken
    Sobel, Jack D.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (05) : 1355 - 1358
  • [2] Pharmacodynamic Evaluation of Rezafungin (CD101) against Candida auris in the Neutropenic Mouse Invasive Candidiasis Model
    Lepak, Alexander J.
    Zhao, Miao
    Andes, David R.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (11)
  • [3] Efficacy of CD101, a Novel Echinocandin, in Mouse Models of Aspergillosis and Azole-Resistant Disseminated Candidiasis
    Ong, Voon
    Bartizal, Ken
    Miesel, Lynn
    [J]. BLOOD, 2016, 128 (22)
  • [4] In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model
    Zhao, Miao
    Lepak, Alexander J.
    VanScoy, Brian
    Bader, Justin C.
    Marchillo, Karen
    Vanhecker, Jamie
    Ambrose, Paul G.
    Andes, David R.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (04)
  • [5] Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species
    Locke, Jeffrey B.
    Almaguer, Amanda L.
    Zuill, Douglas E.
    Bartizal, Ken
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (10) : 6100 - 6107
  • [6] Determination of Pharmacodynamic Target Exposures for Rezafungin against Candida tropicalis and Candida dubliniensis in the Neutropenic Mouse Disseminated Candidiasis Model
    Lepak, Alexander J.
    Zhao, Miao
    Andes, David R.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (11)
  • [7] CD101, a Novel Echinocandin, Possesses Potent Antibiofilm Activity against Early and Mature Candida albicans Biofilms
    Chandra, Jyotsna
    Ghannoum, Mahmoud A.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (02)
  • [8] Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates
    Pfaller, Michael A.
    Messer, Shawn A.
    Rhomberg, Paul R.
    Jones, Ronald N.
    Castanheira, Mariana
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (10) : 2868 - 2873
  • [9] Novel Echinocandin Rezafungin (CD101) In vitro Potency Translates to Efficacious Treatment/Prophylaxis in Mouse Models of Disseminated/Pulmonary Aspergillosis
    Ong, Voon
    Hough, Grayson
    Flanagan, Shawn
    Bartizal, Ken
    Sattar, Abdul
    Sharp, Andrew
    Thommes, Pia
    [J]. BONE MARROW TRANSPLANTATION, 2018, 53 : 572 - 574
  • [10] Time-kill kinetics of the novel echinocandin CD101 for azole-susceptible and - resistant Candida spp. at pH 4 in vagina-simulative medium
    Locke, J. B.
    Almaguer, A. L.
    Bartizal, K.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016, 215 (06) : 822 - 822