Bactericidal effect of graphene oxide/Cu/Ag nanoderivatives against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus

被引：0
|
作者：
Jankauskaite, V. [1 ]
Vitkauskiene, A. [2 ]
Lazauskas, A. [3 ]
Baltrusaitis, J. [4 ]
Prosycevas, I. [3 ]
Andrulevicius, M. [3 ,5 ]
机构：
[1] Kaunas Univ Technol, Fac Mech Engn & Design, Studentu St 56, LT-51424 Kaunas, Lithuania
[2] Lithuanian Univ Hlth Sci, Fac Med, Eiveniu St 2, LT-50009 Kaunas, Lithuania
[3] Kaunas Univ Technol, Inst Mat Sci, Barsausko St 59, LT-51423 Kaunas, Lithuania
[4] Lehigh Univ, Dept Chem & Biomol Engn, B336 Iacocca Hall,111 Res Dr, Bethlehem, PA 18015 USA
[5] Kaunas Univ Technol, Dept Phys, Studentu St 50, LT-51368 Kaunas, Lithuania
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2016年 / 511卷 / 01期
关键词：
Graphene oxide; Ag; Cu; Nanoparticles; Bactericidal effect; Morphology; SILVER NANOPARTICLES; MECHANISMS; TOXICITY;
D O I：
10.1016/j.ijpharma.2016.06.121
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A systematic analysis of antibacterial activity of individual nanoderivatives, e.g. GO nanosheets, Ag and Cu nanoparticles (NPs), as well as combinations of Cu-Ag NPs, and GO-Cu-Ag nanocomposites against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) was performed. Chemical properties of the GO, Cu and Ag NPs were determined employing X-ray photoelectron spectroscopy and X-Ray-excited Auger electron spectroscopy. Morphology of corresponding nanoderivatives was studied employing transmission electron microscopy and scanning electron microscopy. It was shown that combination of Cu and Ag NPs, as well as GO-Cu-Ag nanocomposite material possess enhanced antibacterial activity through a possible synergy between multiple toxicity mechanisms. MRSA showed highest resistance in all cases. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：90 / 97
页数：8
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