Chemical Constituents and Biological Studies of the Leaves of Grevillea robusta

被引：14

作者：

Chuang, Ta-Hsien ^{[1
]}

Chan, Hsiu-Hui ^{[2
,3
]}

Wu, Tian-Shung ^{[1
,2
,3
]}

Li, Chien-Fu ^{[1
]}

机构：

[1] China Med Univ, Sch Pharm, Taichung 40402, Taiwan

[2] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan

[3] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

来源：

MOLECULES | 2011年 / 16卷 / 11期

关键词：

Grevillea robusta; proteaceae; cytotoxicity; DPPH; tyrosinase inhibition activity; PHENOLIC CONSTITUENTS; METABOLITES; FLAVONOIDS; GLYCOSIDES; MARITIMA;

D O I：

10.3390/molecules16119331

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new compounds: Graviquinone (1), cis-3-hydroxy-5-pentadecylcyclohexanone (2), and methyl 5-ethoxy-2-hydroxycinnamate (3), and thirty-eight known compounds were isolated and identified from the leaves of Grevillea robusta. The structures of these compounds were determined by spectroscopic and chemical transformation methods. Graviquinone (1) showed the strongest cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. Methyl 2,5-dihydroxycinnamate (4), graviphane (13), and dehydrograviphane (14) exhibited very potent DPPH scavenging activity compared with a-tocopherol. Methyl 2,5-dihydroxycinnamate (4) and bis-norstriatol (17) demonstrated strong inhibition of L-DOPA oxidation by mushroom tyrosinase compared with kojic acid.

引用

页码：9331 / 9339

页数：9

共 50 条

[1] Chemical Constituents and Biological Activities of Grevillea robusta
Wang, Kui-Wu
Zhang, Ting-Ting
Zhang, Lei
[J]. CHEMISTRY OF NATURAL COMPOUNDS, 2018, 54 (01) : 153 - 155
[2] Chemical Constituents and Biological Activities of Grevillea robusta
Kui-Wu Wang
Ting-Ting Zhang
Lei Zhang
[J]. Chemistry of Natural Compounds, 2018, 54 : 153 - 155
[3] Phenolic constituents from Grevillea robusta
Ahmed, AS
Nakamura, N
Meselhy, MR
Makhboul, MA
El-Emary, N
Hattori, M
[J]. PHYTOCHEMISTRY, 2000, 53 (01) : 149 - 154
[4] The presence of arbutin in leaves of the Grevillea robusta (Proteaceae).
Bourquelot, E
Fichtenholz, A
[J]. COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES, 1912, 154 : 1106 - 1108
[5] NEW PHENOLIC CONSTITUENTS OF GREVILLEA-ROBUSTA WOOD
VARMA, RS
MANJU, M
PARTHASARATHY, MR
[J]. PHYTOCHEMISTRY, 1976, 15 (09) : 1418 - 1419
[6] RUTIN FROM THE LEAVES OF GREVILLEA-ROBUSTA A-CUNN
KOBAYASHI, K
[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1951, 71 (12): : 1493 - 1494
[7] The presence of quebrachine in the leaves if Grevillea robusta A. Cunn.
Bourquelot, E
Fichtenholz, A
[J]. COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES, 1912, 155 : 615 - 617
[8] MINOR PHENOLIC CONSTITUENTS OF GREVILLEA-ROBUSTA AND HAKEA-SALIGNA
VARMA, M
VARMA, RS
PARTHASARATHY, MR
[J]. ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES, 1980, 35 (3-4): : 344 - 345
[9] NUTRITION OF GREVILLEA ROBUSTA
MOORE, CWE
KERAITIS, K
[J]. AUSTRALIAN JOURNAL OF BOTANY, 1966, 14 (02) : 151 - &
[10] STUDIES OF THE MOLECULAR CORE OF GREVILLEA-ROBUSTA GUM
CHURMS, SC
STEPHEN, AM
[J]. CARBOHYDRATE RESEARCH, 1987, 167 : 239 - 255

← 1 2 3 4 5 →