Purification of [18F]-fluoro-L-thymidine ([18F]-FLT) for positron emission tomography imaging

被引：6
|
作者：
Bourgeois, Mickael
Mougin-Degraef, Marie
Leost, Francoise
Cherel, Michel
Gestin, Jean-Francois
Le Bars, Didier
Barbet, Jacques
Faivre-Chauvet, Alain
机构：
[1] Univ Nantes, INSERM, Dept Rech Cancerol, U601,Inst Biol, F-44093 Nantes 1, France
[2] CHU Nantes, F-44093 Nantes 1, France
[3] CERMEP, F-69003 Lyon, France
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2007年 / 45卷 / 01期
关键词：
(1S)]-fluoro-L-thyrnidine; FLT; positron emission tomography; oncology; purification;
D O I：
10.1016/j.jpba.2007.04.034
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
3'-Deoxy-3'-[F-18]fluorothyinidine ([F-18]-FLT) has recently been described as a positron emission tomography (PET) radiopharmaceutical for visualizing cellular proliferation in vivo. All published radiosyntheses of [F-18]-FLT provide crude products that must be purified before injection to human. This study describes a reliable purification procedure for [F-18]-FLT. It is based on HPLC. In 17.9 +/- 0.5 min, pure [F-18]-FLT is obtained that could be injected to human after a passage through a sterile 0.22 mu m filter. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：154 / 157
页数：4
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