Macrocycle Therapeutics to Treat Life-threatening Diseases

被引：3
|
作者：
Batur, Gokhan [1 ]
Ermert, Philipp [1 ]
Zimmermann, Johann [1 ]
Obrecht, Daniel [1 ]
机构：
[1] Polyphor Ltd, Hegenheimermattweg 125, CH-4123 Allschwil, Switzerland
来源：
CHIMIA | 2021年 / 75卷 / 06期
关键词：
Antibiotic; Breast cancer; CXCR4; inhibitor; Macrocycle; Protein epitope mimetic; SYNTHETIC PEPTIDE; CXCR4; POTENT; CHEMOTHERAPY; MOBILIZATION; METASTASIS; ANTAGONIST; INHIBITOR; DISCOVERY; THANATIN;
D O I：
10.2533/chimia.2021.508
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polyphor's macrocycle platform led to the discovery of novel antibiotics addressing specifically Gramnegative bacteria by targeting outer membrane proteins. Furthermore, POL6014, an inhibitor of neutrophile elastase and balixafortide, a CXCR4 inhibitor have been discovered and developed from the platform. Currently a combination of balixafortide and eribulin is in Phase III clinical trial for the treatment of patients with advanced metastatic HER2-negative breast cancer.
引用
收藏
页码：508 / 513
页数：6
相关论文
共 50 条
  • [1] HOW TO TREAT SYMPTOMATIC ARRHYTHMIA THAT IS NOT LIFE-THREATENING
    OHARA, G
    CANADIAN JOURNAL OF CARDIOLOGY, 1994, 10 (03) : 331 - 332
  • [2] Life-threatening cutaneous viral diseases
    Rebora, A
    CLINICS IN DERMATOLOGY, 2005, 23 (02) : 157 - 163
  • [3] Eruptions in life-threatening rheumatologic diseases
    Engin, Burhan
    Sevim, Aysegul
    Cesur, Seher Kucukoglu
    Tuzun, Yalcin
    CLINICS IN DERMATOLOGY, 2020, 38 (01) : 86 - 93
  • [4] Use of extracorporeal therapies to treat life-threatening intoxications
    Deville, Kyle
    Charlton, Nathan
    Askenazi, David
    PEDIATRIC NEPHROLOGY, 2024, 39 (01) : 105 - 113
  • [5] Use of extracorporeal therapies to treat life-threatening intoxications
    Kyle Deville
    Nathan Charlton
    David Askenazi
    Pediatric Nephrology, 2024, 39 : 105 - 113
  • [6] Extratracheal biodegradable splint to treat life-threatening tracheomalacia
    Bugmann, P
    Rimensberger, PC
    Kalangos, A
    Barazzone, C
    Beghetti, M
    Lang, FJW
    ANNALS OF THORACIC SURGERY, 2004, 78 (04): : 1446 - 1448
  • [7] New agents to treat life-threatening fungal infections
    Ting, Pauline C.
    Walker, Scott S.
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (07) : 592 - 602
  • [8] ANTIOXIDANTS, NUTRITIONAL SUPPLEMENTS AND LIFE-THREATENING DISEASES
    GUTTERIDGE, JMC
    BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 1994, 51 (03) : 288 - 295
  • [9] Rare highly contagious and life-threatening Diseases
    Gottschalk, Rene
    Herzog, Christian
    BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, 2015, 58 (07) : 655 - 656
  • [10] Life-threatening respiratory diseases or allergies in sport
    Drobnic, Franchek
    Sala, Anna
    Labrador, Moises
    Unnithan, Viswanath
    Cardona, Victoria
    APUNTS-MEDICINA DE L ESPORT, 2015, 50 (185): : 35 - 42
12345