Glutathione and its metabolizing enzymes in patients with different benign and malignant diseases

被引：59
|
作者：
Abou Ghalia, AH [1 ]
Fouad, IM
机构：
[1] Ain Shams Fac Med, Dept Biochem, Oncol Diagnost Unit, Cairo, Egypt
[2] Ain Shams Fac Med, Dept Radiotherapy, Cairo, Egypt
来源：
CLINICAL BIOCHEMISTRY | 2000年 / 33卷 / 08期
关键词：
GSH; GSH-Px; GST; GR; breast; ovarian; prostate; liver; neoplasms;
D O I：
10.1016/S0009-9120(00)00181-8
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Objectives: Evaluation of glutathione (GSH) system in different tumors to reveal its potential usefulness in a clinical setting. Design and methods: In addition to 10 normal controls, blood and tissue samples (85 benign and 109 malignant) from patients with breast, ovarian, prostatic, and liver neoplasms were investigated. The GSH concentration, glutathione S-transferase, glutathione peroxidase, and glutathione reductase activities were biochemically measured. Results: Whereas all the components of the GSH system increased in patients with breast tumors, few components were significantly changed in patients with malignant ovarian, prostatic as well as metastatic liver diseases. GSH had the highest Z scores in ovarian and breast tumors. It was correlated (p < 0.05) with both glutathione S-transferase, glutathione peroxidase in breast cancer and with glutathione S-transferase only in prostate cancer. No correlation could be found in the expression of the GSH system in the blood and tissues of the same group of patients. Conclusion: This work revealed that measurement of some and/or all components of the GSH system might be of clinical value in some malignant cases. Copyright (C) 2001 The Canadian Society of Clinical Chemists.
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收藏
页码：657 / 662
页数：6
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