Halide inhibition of the copper-catalysed azide-alkyne cycloaddition

被引：14
|
作者：
Moorman, Rebekah M. [1 ]
Collier, Matthew B. [1 ]
Frohock, Bram H. [1 ]
Womble, Michael D. [1 ]
Chalker, Justin M. [1 ]
机构：
[1] Univ Tulsa, Dept Chem & Biochem, Tulsa, OK 74104 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 07期
关键词：
CLICK CHEMISTRY; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES;
D O I：
10.1039/c4ob02479f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chloride, bromide and iodide are inhibitors of the copper-catalysed azide-alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction.
引用
收藏
页码：1974 / 1978
页数：5
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