Effects of triethylene tetraamine on the G-quadruplex structure in the human c-myc promoter

被引：9
|
作者：
Yin, Fei
Liu, Jianhui [1 ]
Deng, Xiaohong
Wang, Jingyun
机构：
[1] Chongqing Technol & Business Univ, Res Ctr Pharmaceut Chem & Chemobiol, Chongqing, Peoples R China
[2] Chongqing Technol & Business Univ, Coll Environm & Bioengn, Chongqing 400067, Peoples R China
[3] Dalian Univ Technol, Coll Environm & Bioengn, Dalian 116023, Peoples R China
来源：
JOURNAL OF BIOCHEMISTRY | 2007年 / 141卷 / 05期
关键词：
c-Myc; G-quadruplex; telomerase; triethylene tetraamine;
D O I：
10.1093/jb/mvm069
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The increasing data show that a parallel G-quadruplex structure formed by the element of nuclease-hypersensitivity element III1 (NHE III1) in the P1 promoter of c-myc functions as a transcriptional repressor. Triethylene tetraamine has exhibited interesting properties of stabilizing both inter- and intra-molecular G-quadruplex structures and telomerase-inhibitory potency. Here, we present evidences showing that triethylene tetraamine facilitates the formation of G-quadruplex structure by the NHE III1 element, and inhibits the expression of c-myc in HeLa cells.
引用
收藏
页码：669 / 674
页数：6
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