Regulation of the p53 pathway by ubiquitin and related proteins

被引：59
|
作者：
Hock, Andreas [1 ]
Vousden, Karen H. [1 ]
机构：
[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 10期
关键词：
p53; MDM2; Ubiquitination; SUMOylation; NEDDylation; DEUBIQUITINATING ENZYME USP2A; DNA-DAMAGE; LIGASE; MDM2; SUBSTRATE; UBIQUITYLATION; ACETYLATION; PROMOTES; ACTS;
D O I：
10.1016/j.biocel.2010.06.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p53 tumour suppressor protein is subject to many levels of control, including modification with ubiquitin and related proteins such as SUMO and NEDD8. These modifications regulate p53 at a number of levels, including control of protein turnover, alterations in sub-cellular localization and changes in the ability to regulate gene expression. Numerous E3 ligases that can mediate these modifications of p53 have been described, some of which promote conjugation with more than one ubiquitin-like protein. Understanding the complexity of this mechanism of p53 regulation will help in the development of therapeutic drugs that function to modulate these events. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1618 / 1621
页数：4
相关论文
共 50 条
  • [1] Regulation of the p53 Family Proteins by the Ubiquitin Proteasomal Pathway
    Bang, Scott
    Kaur, Sandeep
    Kurokawa, Manabu
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (01)
  • [2] p53 regulation by ubiquitin
    Brooks, Christopher L.
    Gu, Wei
    [J]. FEBS LETTERS, 2011, 585 (18): : 2803 - 2809
  • [3] The role of ubiquitin modification in the regulation of p53
    Hock, Andreas K.
    Vousden, Karen H.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2014, 1843 (01): : 137 - 149
  • [4] p53 regulation by ubiquitin and ubiquitin-like modifications
    Ying Wang
    Chenlu Zhang
    Jiabao Wang
    Jiang Liu
    [J]. Genome Instability & Disease, 2022, 3 (4) : 179 - 198
  • [5] Correction to: p53 regulation by ubiquitin and ubiquitin-like modifications
    Ying Wang
    Chenlu Zhang
    Jiabao Wang
    Jiang Liu
    [J]. Genome Instability & Disease, 2022, 3 (4) : 199 - 200
  • [6] Participation of P53 family proteins in the oligodendroglial differentiation regulation by the ubiquitin-proteasome system
    Calatayud, CA
    Soto, EF
    Pasquini, JM
    Pasquini, LA
    [J]. JOURNAL OF NEUROCHEMISTRY, 2006, 96 : 55 - 55
  • [7] Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma
    Anwar, A.
    Shellman, Y. G.
    Norris, D. A.
    Fujita, M.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 : S21 - S21
  • [8] Limiting the power of p53 through the ubiquitin proteasome pathway
    Pant, Vinod
    Lozano, Guillermina
    [J]. GENES & DEVELOPMENT, 2014, 28 (16) : 1739 - 1751
  • [9] Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma
    Anwar, Adil
    Norris, David A.
    Fujita, Mayumi
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2011, 508 (02) : 198 - 203
  • [10] The regulation of p53 by phosphorylation: A model for how distinct signals Integrate into the p53 pathway
    Maclaine, Nicola J.
    Hupp, Ted R.
    [J]. AGING-US, 2009, 1 (05): : 490 - 502
12345