A mild synthesis of nitriles by TPPX2-promoted dehydration of primary amides

被引：0
|
作者：
Vaccari, Daniele [1 ]
Davoli, Paolo [1 ]
Bucciarelli, Maria [1 ]
Spaggiari, Alberto [1 ]
Prati, Fabio [1 ]
机构：
[1] Univ Modena & Reggio Emilia, Dipartimento Chim, I-41100 Modena, Italy
来源：
LETTERS IN ORGANIC CHEMISTRY | 2007年 / 4卷 / 05期
关键词：
dehydration; dehydrohalogenation; halotriphenoxy phosphonium halides; imidoyl halides; nitriles; phosphonium salts;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expeditious route to nitriles via dehydration of primary amides using halotriphenoxy phosphonium halides (TPPX2, X = Cl or Br) is described. The reaction proceeds under very mild conditions and allows the preparation of aromatic and aliphatic nitriles in good to excellent yields.
引用
收藏
页码：319 / 321
页数：3
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