Safety and immunogenicity of prepandemic H5N1 influenza vaccines: A systematic review of the literature

被引：24
|
作者：
Prieto-Lara, Elisa [1 ]
Llanos-Mendez, Aurora [1 ]
机构：
[1] Andalusian Agcy Hlth Technol Assessment, Emerging Technol Observ, Seville 41020, Spain
来源：
VACCINE | 2010年 / 28卷 / 26期
关键词：
Influenza A virus; Subtype H5N1; Avian influenza; Prepandemic vaccines; Immunogenicity; Safety; Systematic review; MULTIPLE-TREATMENTS; ADULTS;
D O I：
10.1016/j.vaccine.2010.03.068
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A systematic review was performed to assess the safety and immunogenicity of the prepandemic H5N1 influenza vaccines licensed so far. A bibliographic search according to the COSI protocol was carried Out and 8 of 235 potentially relevant publications were selected. Quality assessment was defined with both CASP and Jadad checklists. Taken together, the results from the present systematic review suggest that the inactivated split-virion formulation that includes a low antigen dose (3.8 mu g) and an oil-in-water emulsion-based adjuvant, represents the best option in the case of a pandemic, due to its antigen-sparing capacity and its favorable safety profile. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4328 / 4334
页数：7
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