Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat

被引:13
|
作者
Lee, Bombi [2 ,3 ]
Yang, Chae Ha [4 ]
Hahm, Dae-Hyun [5 ]
Lee, Hye-Jung [5 ]
Choe, Eun Sang [6 ]
Pyun, Kwang-Ho [1 ]
Shim, Insop [1 ]
机构
[1] Catholic Univ, Coll Med, Dept Integrat Med, Seoul 137701, South Korea
[2] Childrens Hosp, Div Neurosci, Dept Neurobiol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Daegu Haany Univ, Coll Oriental Med, Dept Physiol, Taegu, South Korea
[5] Kyung Hee Univ, Grad Sch E W Med Sci, Dept Oriental Med Sci, Suwon, South Korea
[6] Pusan Natl Univ, Div Biol Sci, Pusan 609735, South Korea
关键词
D O I
10.1211/jpp.59.12.0008
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Repeated injections of nicotine can produce an increase in locomotor activity and the expression of immediate-early gene, c-fos, in the central dopaminergic areas. Many studies have shown that Coptidis Rhizoma (CR) and its main alkaloid compound, berberine (BER), have a suppressive effect on the central nervous system. We examined the influence of CR or BER on repeated nicotine-induced locomotor activity in rats and the change of c-Fos expression in the brain by using immunohistochemistry. Male Sprague-Dawley rats were given CR and BER before repeated injections of nicotine hydrochloride (0.4 mg kg(-1), s.c.) twice daily for 7 days. After 3 days withdrawal, rats received a challenge injection of nicotine. Pretreatment with CR (100 mg kg(-1), i.p.) and BER (100 mg kg(-1), i.p.) significantly inhibited the nicotine-induced locomotor activity and expression of c-Fos in the striatum and the nucleus accumbens. These results suggest that CR and BER may produce inhibitory effects of nicotine on behavioural sensitization by possibly reducing postsynaptic neuronal activation in the central dopaminergic systems.
引用
收藏
页码:1663 / 1669
页数:7
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