Protection of rabbits against rabbit viral haemorrhagic disease with a vaccinia-RHDV recombinant virus

被引：45

作者：

Bertagnoli, S

Gelfi, J

Petit, F

Vautherot, JF

Rasschaert, D

Laurent, S

LeGall, G

Boilletot, E

Chantal, J

BoucrautBaralon, C

机构：

[1] INRA, UNITE VIROL & IMMUNOL MOL, F-78350 JOUY EN JOSAS, FRANCE

[2] CNEVA, LAB CENT RECH AVICOLE & PORCINE, F-22440 PLOUFRAGAN, FRANCE

来源：

VACCINE | 1996年 / 14卷 / 06期

关键词：

RVHD; recombinant vaccinia virus; vaccination;

D O I：

10.1016/0264-410X(95)00232-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to protect domestic and wild rabbits against RVHD, we constructed a recombinant vaccinia-RHDV virus, using the Copenhagen strain of the vaccinia virus. This recombinant virus expressed the RHDV capsid protein (VP60). Analysis of the expressed product showed that the recombinant protein, which is 60 kDa in size, was antigenic as revealed by its reactions in immunoprecipitation and indirect immunofluorescence with the antibodies raised against RHDV. The recombinant virus induced high level of RHDV specific antibodies in rabbits following immunization. Inoculations by both the intradermal and oral routes allow protection of animals against a challenge with virulent RHDV. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：506 / 510

页数：5

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