Synthesis and characterisation of new fluorescent Na+ and K+ indicators

被引：0
|
作者：
Heyen, KV [1 ]
Cielen, E [1 ]
Tahri, A [1 ]
Saleh, A [1 ]
Boens, N [1 ]
Hoornaert, GJ [1 ]
机构：
[1] Katholieke Univ Leuven, Dept Chem, B-3001 Heverlee, Belgium
来源：
TETRAHEDRON | 1999年 / 55卷 / 16期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of new fluorescent indicators for Na+, Benz-15-5 or Diaz-15-5, and for K+, Bent-18-6 or Diaz-18-6, respectively, is reported. They consist of a benzocrown or a diazacrown ether linked to a pyrazoline fluorophore substituted with carboxylate groups to ensure water solubility. They were obtained via reaction of an alpha,beta-unsaturated ketone with an aryl hydrazine. The fluorescence intensity of Bent-15-5 is nearly insensitive to Na+. Bent-18-6 displays a four-fold selectivity for K+ over Na+, with a dissociation constant of 3.6 mM for the K+:indicator complex. Diaz-15-5 and Diaz-18-6 have only a weak affinity for monovalent cations, so that they only can be used for the determination of high Na+ and K+ concentrations. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：5207 / 5226
页数：20
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