CBr4-Promoted Efficient Synthesis of 2-(1H-Benzo[d]imidazol-2-yl)-3-arylacrylonitriles

被引：2

作者：

Wang, Xiang ^{[1
]}

Chen, Ping ^{[1
]}

Zhi, Sanjun ^{[1
]}

Hu, Huayou ^{[1
]}

Kan, Yuhe ^{[1
]}

机构：

[1] Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 11期

基金：

中国国家自然科学基金;

关键词：

benzimidazol; carbon tetrabromide; acrylonitrilel; Knoevenagel condensation; KNOEVENAGEL CONDENSATION; IN-VITRO; BENZIMIDAZOLES; INHIBITORS;

D O I：

10.6023/cjoc201804037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(1H-Benzo[d]imidazol-2-yl)-3-arylacrylonitrile derivatives not only exhibit a variety of important biological activities, but also are important intermediates in organic synthesis. The CBr4-promoted reaction of aromatic aldehydes with 2-(1H-benzo[d]imidazol-2-yl)acetonitrile to obtain 2-(1H-benzo[d]imidazol-2-yl)-3-arylacrylonitriles was developed. Structurally diverse 2-(1H-benzo[d]imidazol-2-yl)-3-anlacrylonitriles were obtained in moderate to good yields (74%-96%) under mild conditions. This method has the advantages of operational simplicity and wide substrate scope.

引用

页码：3123 / 3126

页数：4

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