Synthesis and Surface Modification of Highly Fluorescent Gold Nanoclusters and Their Exploitation for Cellular Labeling

被引：1

作者：

Lin, Cheng-An J. ^{[1
,4
]}

Lee, Chih-Hsien ^{[1
,4
]}

Hsieh, Jiun-Tai ^{[1
,4
]}

Yu, Wan-Chun ^{[1
,4
]}

Yang, Hong-Zhi ^{[1
,4
]}

Li, Jimmy K. ^{[5
]}

Sperling, Ralph ^{[2
]}

Wang, Hsueh-Hsiao ^{[3
]}

Yeh, Hung-, I ^{[3
]}

Parak, Wolfgang J. ^{[2
]}

Chang, Walter H. ^{[1
,4
]}

机构：

[1] Chung Yuan Christian Univ, Dept Biomed Engn, Chungli, Taiwan

[2] Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany

[3] Mackay Mem Hosp, Cardiac Med, Taipei, Taiwan

[4] Chung Yuan Christian Univ, Ctr Nano Bioengn, Chungli, Taiwan

[5] Natl Univ Tainan, Dept Mat Sci, Tainan 70005, Taiwan

来源：

COLLOIDAL QUANTUM DOTS FOR BIOMEDICAL APPLICATIONS V | 2010年 / 7575卷

关键词：

fluorescent gold nanoclusters; bioconjugation; near infrared; cell labeling; PEGylation; biotinylation; lipoic acid; QUANTUM DOTS; INFRARED LUMINESCENCE; NANOPARTICLES; CLUSTERS; SIZE; NANOCRYSTALS; AU; PHOTOLUMINESCENCE; MOLECULES; SPECTRA;

D O I：

10.1117/12.841540

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We introduce a general approach to make colorful fluorescent gold nanoclusters which are protected by dihydrolipoic acid, mercaptoundecanoic acid and polyethylenimine. The fluorescent gold nanoclusters can perform a variety of bioconjugation processes such as PEGylation, biotinylation as well as forming complex nanobioconjugates with streptavidins. The brightening effects under proper surface modification are also reported. The clusters have a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules. Nonspecific uptake by human aortic endothelial cells is demonstrated.

引用

页数：9

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