Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells

被引：4
|
作者：
Lee, Hye-Yeon [1 ,2 ]
Kim, Juri [1 ,2 ]
Ryu, Jae-Sook [3 ]
Park, Soon-Jung [1 ,2 ]
机构：
[1] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 03722, South Korea
[2] Yonsei Univ, Coll Med, Inst Trop Med, Brain Korea PLUS Project Med Sci 21, Seoul 03722, South Korea
[3] Hanyang Univ, Coll Med, Dept Environm Biol & Med Parasitol, Seoul 04763, South Korea
来源：
KOREAN JOURNAL OF PARASITOLOGY | 2017年 / 55卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Trichomonas vaginalis; alpha-actinin; 2; Treg cell; interleukin-10 (IL-10); PROINFLAMMATORY CYTOKINE; IDENTIFICATION; MACROPHAGES; INDUCTION; PROTEINS; WOMEN; FOXP3;
D O I：
10.3347/kjp.2017.55.4.375
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis alpha-actinin 2, Tv alpha-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tv alpha-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tv alpha-actinin 2 anti-bodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tv alpha-actinin 2 protein. Both T. vaginalis and rTva-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4(+)CD25(-) regulatory T cells (Treg cells) incubated with rTv alpha-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tv alpha-actinin 2 modulates immune responses via IL-10 production by Treg cells.
引用
收藏
页码：375 / 384
页数：10
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