Self-testing and self-management of oral anticoagulation therapy in children

被引:17
|
作者
Christensen, Thomas Decker [1 ,2 ]
Larsen, Torben Bjerregaard [3 ,4 ]
Hjortdal, Vibeke E. [1 ,2 ]
机构
[1] Aarhus Univ Hosp, Dept Cardiothorac & Vasc Surg, DK-8200 Aarhus N, Denmark
[2] Aarhus Univ Hosp, Inst Clin Med, DK-8200 Aarhus N, Denmark
[3] Aalborg Hosp, Dept Cardiol, Aalborg, Denmark
[4] Univ Aalborg, Dept Hlth Sci & Technol, Aalborg, Denmark
关键词
Paediatric; self-testing; self-management; anticoagulation; point of care; INTERNATIONAL NORMALIZED RATIO; EXTERNAL QUALITY ASSESSMENT; MECHANICAL VALVE-REPLACEMENT; PROTHROMBIN TIME; WARFARIN THERAPY; COAGUCHEK-XS; POINT; INR; HOME; ACCURACY;
D O I
10.1160/TH11-04-0217
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Children and adolescents on oral anticoagulation therapy (OAT) present special challenges in terms of rapid fluctuations in International Normalised Ratio (INR) values, interruption in dai y life due to frequent hospital/doctor visits, and difficulties and pain in the performance of venepuncture. Optimised management of OAT in proves the quality of treatment, potentially accomplished by new methods such as patient self-testing (PST) and patient self-management (PSM). A review was performed, identifying 11 trials with children and adolescents. All studies had different methodological problem;, predominantly by being non-randomised trials. A total of 284 patients were included with a mean follow-up of 22 months, finding a time within therapeutic IN R target range between 63% and 84%. The coagulmeters used for estimating the IN R values were found to have sufficient precision and accuracy for clinical use, but external quality control is probably advisable. It can be concluded that PST and PSM are at least as good treatment options as conventional management in highly selected children. Larger studies, preferably randomised, controlled trials using clinical endpoints, are obviously needed in order to elucidate whether these new regimens of treatment are superior to conventional management of oral anticoagulation therapy.
引用
收藏
页码:391 / 397
页数:7
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