Gallium(III) triflate-catalyzed one-pot selective synthesis of 2 3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H)-ones

被引：288
|
作者：
Chen, Jiuxi [1 ]
Wu, Dengze [1 ]
He, Fei [1 ]
Liu, Miaochang [1 ]
Wu, Huayue [1 ]
Ding, Jinchang [1 ]
Su, Weike [1 ,2 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Zhejiang Key Lab Pharmaceut Engn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 23期
基金：
中国国家自然科学基金;
关键词：
gallium(III) triflate; 2,3-dihydroquinazolin-4(1H)-ones; quinazolin-4(3H)-ones; one-pot; selective synthesis;
D O I：
10.1016/j.tetlet.2008.03.127
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2,3-dihydroquinazolin-4(1H)-ones and quinazolin-4(3H) -ones have been synthesized in good to excellent yields and high selectivity by one-pot reaction using isatoic anhydride, ammonium acetate (or amines), and aldehydes in ethanol or in DMSO under mild conditions, respectively. The reaction was efficiently prompted by 1 mol % Ga(OTf)(3) and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity. (C) 2008 Published by Elsevier Ltd.
引用
收藏
页码：3814 / 3818
页数：5
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