High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men

被引：231

作者：

Gnjidic, D. ^{[1
,2
,3
,4
]}

Hilmer, S. N. ^{[1
,2
,3
]}

Blyth, F. M. ^{[3
,4
]}

Naganathan, V. ^{[3
,4
]}

Cumming, R. G. ^{[3
,4
,5
]}

Handelsman, D. J. ^{[3
,6
]}

McLachlan, A. J. ^{[4
,7
]}

Abernethy, D. R. ^{[8
]}

Banks, E. ^{[9
]}

Le Couteur, D. G. ^{[3
,4
,6
]}

机构：

[1] Royal N Shore Hosp, Dept Clin Pharmacol, Sydney, NSW, Australia

[2] Royal N Shore Hosp, Dept Aged Care, Sydney, NSW, Australia

[3] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[4] Concord Hosp, Ctr Educ & Res Ageing, Concord, Australia

[5] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[6] Concord Hosp, ANZAC Med Inst, Concord, Australia

[7] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia

[8] US FDA, Off Clin Pharmacol, Silver Spring, MD USA

[9] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 91卷 / 03期

基金：

英国医学研究理事会;

关键词：

DRUG BURDEN INDEX; RESIDENTIAL AGED CARE; CLINICAL-PHARMACOLOGY; CONCORD HEALTH; PHYSICAL FUNCTION; SHORT-FORM; PEOPLE; IMPACT; ADULTS; PROJECT;

D O I：

10.1038/clpt.2011.258

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Evidence about the association between treatment with high-risk medicines and frailty in older individuals is limited. We investigated the relationship between high-risk prescribing and frailty at baseline, as well as 2-year incident frailty, in 1,662 men >= 70 years of age. High-risk prescribing was defined as polypharmacy (>= 5 medicines), hyperpolypharmacy (>= 10 medicines), and by the Drug Burden Index (DBI), a dose-normalized measure of anticholinergic and sedative medicines. At baseline, frail participants had adjusted odds ratios (ORs) of 2.55 (95% confidence interval, Cl: 1.69-3.84) for polypharmacy, 5.80 (95% Cl: 2.90-11.61) for hyperpolypharmacy, and 2.33 (95% Cl: 1.58-3.45) for DBI exposure, as compared with robust participants. Of the 1,242 men who were robust at baseline, 6.2% developed frailty over two years. Adjusted ORs of incident frailty were 2.45 (95% Cl: 1.42-4.23) for polypharmacy, 2.50 (95% Cl: 0.76-8.26) for hyperpolypharmacy, and 2.14 (95% Cl: 1.25-3.64) for DBI exposure. High-risk prescribing may contribute to frailty in community-dwelling older men.

引用

页码：521 / 528

页数：8

共 50 条

[1] HIGH RISK PRESCRIBING AND INCIDENCE OF FRAILTY AMONG OLDER COMMUNITY-DWELLING MEN.
Gnjidic, D.
Hilmer, S. N.
Le Couteur, D. G.
Abernethy, D. R.
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 : S14 - S14
[2] PREVALENCE AND INCIDENCE OF FRAILTY AMONG COMMUNITY-DWELLING OLDER ADULTS IN SLOVENIA
Jazbar, Janja
Pisek, Spela
Locatelli, Igor
Kos, Mitja
[J]. ZDRAVSTVENO VARSTVO, 2021, 60 (03): : 190 - 198
[3] Metabolites Associated with Vigor to Frailty Among Community-Dwelling Older Black Men
Marron, Megan M.
Harris, Tamara B.
Boudreau, Robert M.
Clish, Clary B.
Moore, Steven C.
Murphy, Rachel A.
Murthy, Venkatesh L.
Sanders, Jason L.
Shah, Ravi, V
Tseng, George C.
Wendell, Stacy G.
Zmuda, Joseph M.
Newman, Anne B.
[J]. METABOLITES, 2019, 9 (05):
[4] FEAR OF FALLING AMONG HIGH-RISK, URBAN, COMMUNITY-DWELLING OLDER ADULTS
Greenberg, S. A.
[J]. GERONTOLOGIST, 2013, 53 : 13 - 13
[5] Sleep Disturbances and Frailty Status in Older Community-Dwelling Men
Ensrud, Kristine E.
Blackwell, Terri L.
Redline, Susan
Ancoli-Israel, Sonia
Paudel, Misti L.
Cawthon, Peggy M.
Dam, Thuy-Tien L.
Barrett-Connor, Elizabeth
Leung, Ping C.
Stone, Katie L.
[J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2009, 57 (11) : 2085 - 2093
[6] Incidence of Frailty in Community-Dwelling United States Older Veterans
Ganta, Nagapratap
Sikandar, Sehrish
Ruiz, Sergio J.
Nasr, Lubna A.
Mohammed, Yaqub Nadeem
Aparicio-Ugarriza, Raquel
Cevallos, Victor
Tang, Fei
Ruiz, Jorge G.
[J]. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2021, 22 (03) : 564 - 569
[7] Incidence of frailty among community-dwelling older adults: a nationally representative profile in China
Weihao Xu
Ya-Xi Li
Chenkai Wu
[J]. BMC Geriatrics, 19
[8] Incidence of frailty among community-dwelling older adults: a nationally representative profile in China
Xu, Weihao
Li, Ya-Xi
Wu, Chenkai
[J]. BMC GERIATRICS, 2019, 19 (01)
[9] Measuring fear of falling among high-risk, urban, community-dwelling older adults
Greenberg, Sherry A.
Sullivan-Marx, Eileen
Sommers, Marilyn S.
Chittams, Jesse
Cacchione, Pamela Z.
[J]. GERIATRIC NURSING, 2016, 37 (06) : 489 - 495
[10] Frailty in Community-Dwelling Older People
Gobbens, Robbert J.
[J]. HEALTHCARE, 2023, 11 (16)

← 1 2 3 4 5 →