This paper presents a new approach to preparation of neodymium vanadate nanostructures via facile sono-chemical route. Several parameters were compared to reach optimum size and uniformity of as-made samples. These factors include sonication time, sonication power, solvent and using ethylenediamine as alkaline and capping agent, for the first time. Neodymium vanadate nano-photocatalyst applied in decolouration of dye as organic contaminant. Effect of type of dye, type of irradiation source, pH and catalyst loading was described on improving efficiency of catalyst function. Numerous techniques were specified in order to determine purity, morphology and optical properties of products consist XRD, FT-IR, EDX, SEM, TEM and DRS.