Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?

被引：135

作者：

Brown, Paul D. ^{[1
]}

Ahluwalia, Manmeet S. ^{[2
]}

Khan, Osaama H. ^{[3
]}

Asher, Anthony L. ^{[5
,6
]}

Wefel, Jeffrey S. ^{[7
]}

Gondi, Vinai ^{[3
,4
]}

机构：

[1] Mayo Clin, 200 First St SW, Rochester, MN 55905 USA

[2] Cleveland Clin, Cleveland, OH 44106 USA

[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Northwestern Med Canc Ctr, Warrenville, IL USA

[5] Carolina Neurosurg & Spine Associates, Charlotte, NC USA

[6] Carolinas HealthCare Syst, Neurosci Inst, Charlotte, NC USA

[7] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2018年 / 36卷 / 05期

关键词：

CELL LUNG-CANCER; POSTOPERATIVE STEREOTACTIC RADIOSURGERY; MODERATE VASCULAR DEMENTIA; MULTICENTER PHASE-II; OPEN-LABEL; RADIATION-THERAPY; SURGICAL RESECTION; SINGLE METASTASES; BREAST-CANCER; DOUBLE-BLIND;

D O I：

10.1200/JCO.2017.75.9589

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An estimated 20% of patients with cancer will develop brain metastases. Approximately 200,000 individuals in the United States alone receive whole-brain radiotherapy (WBRT) each year to treat brain metastases. Historically, the prognosis of patients with brain metastases has been poor; however, with new therapies, this is changing. Because patients are living longer following the diagnosis and treatment of brain metastases, there has been rising concern about treatment-related toxicities associated with WBRT, including neurocognitive toxicity. In addition, recent clinical trials have raised questions about the use of WBRT. To better understand this rapidly changing landscape, this review outlines the treatment roles and toxicities of WBRT and alternative therapies for the management of brain metastases.

引用

页码：483 / +

页数：10

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