Microwave-enhanced Fischer reaction:: An efficient one-pot synthesis of γ-carbolines

被引：13
|
作者：
Chen, Jing [1 ]
Chen, Weiliang [1 ]
Hu, Yongzhou [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Peoples R China
来源：
SYNLETT | 2008年 / 01期
关键词：
gamma-carbolines; N-acetyl-3-bromo-4-piperidone hydrobromide; arylhydrazine hydrochloride; Fischer reaction; microwave irradiation;
D O I：
10.1055/s-2007-99241
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
gamma-Carbotines were obtained in a simple one-pot Fischer reaction starting from N-acetyl-3-bromo-4-piperidone hydrobromide and substituted arylhydrazine hydrochlorides in acidic media under microwave irradiation or by a thermal process. The optimization procedures are reported in detail, and the results from microwave processes are compared with conventional ones.
引用
收藏
页码：77 / 82
页数：6
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