Decoding cytosolic Ca2+ oscillations

被引：181
|
作者：
Parekh, Anant B. [1 ]
机构：
[1] Dept Physiol Anat & Genet, Oxford OX1 3PT, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2011年 / 36卷 / 02期
基金：
英国医学研究理事会;
关键词：
PROTEIN-KINASE-C; ACTIVATES CRAC CHANNELS; CAMP-RESPONSIVE ELEMENT; NITRIC-OXIDE SYNTHASE; PLASMA-MEMBRANE; CALCIUM-CHANNEL; NEUROTRANSMITTER RELEASE; MAST-CELLS; ENDOPLASMIC-RETICULUM; INTRACELLULAR CA2+;
D O I：
10.1016/j.tibs.2010.07.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A rise in cytosolic Ca2+ concentration is used as a universal signalling mechanism to control biological processes as diverse as exocytosis, contraction, cell growth and cell death. Ca2+ signals are often presented to cells in the form of Ca2+ oscillations, with signalling information encoded in both amplitude and frequency of the Ca2+ spikes. Recent studies have revealed that the sub-cellular spatial profile of the Ca2+ oscillation is also important in activating cellular responses, thereby suggesting a new mechanism for extracting information from the ubiquitous Ca2+ oscillation.
引用
收藏
页码：78 / 87
页数：10
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