The Role of Mitochondrial Energetics and Inflammasome NLRP3 in Diabetic Cardiomyopathy

被引：0

作者：

Almas, Maha ^{[1
]}

Tahir, Usaal ^{[2
]}

Zameer, Mariam ^{[2
]}

Mazhar, Maham ^{[2
]}

Ali, Qurban ^{[2
]}

Rafique, Ayesha ^{[2
]}

Khan, Khushbukhat ^{[3
]}

机构：

[1] Univ Punjab, Ctr Appl Mol Biol, 87-West Canal Bank Rd, Lahore 53700, Pakistan

[2] Univ Lahore, Inst Mol Biol & Biotechnol, 1KM Def Rd, Lahore, Pakistan

[3] Natl Univ Sci & Technol NUST, Attaur Rehman Sch Appl Biosci ASAB, Sector H 12, Islamabad 44000, Pakistan

来源：

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2021年 / 33卷 / 42B期

关键词：

Diabetic cardiomyopathy; inflammasome; mitochondrial energetics; caspases-1; interleukin IL-1 beta; interleukin IL-18; MYOCARDIAL DYSFUNCTION; ACTIVATION; INHIBITOR; MECHANISMS; DISEASE; IMPACT;

D O I：

10.9734/JPRI/2021/v33i42B32449

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diabetic Cardiomyopathy is the worldwide leading cause of lethal heart disorders burdening the healthcare systems. Mitochondrion is the key regulator of myocardial metabolism. It fuels the cardiocytes and regulates the pumping activity of heart. People living with diabetes have defected myocardial metabolism which may likely to cause ventricular dysfunction or other heart disorders due to mitochondrial DNA (mtDNA) mutation. Furthermore, the inflammatory injury due to inflammasome activation is a potent contributor to the cardiac injuries. Though the mechanism of inflammation is still poorly known. This review highlights the association of altered mitochondrial energetics and inflammasome activation with cardiomyopathies.

引用

页码：309 / 315

页数：7

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