Direct organocatalytic regioselective α-hydroxyamination of α-branched aldehydes

被引：0
|
作者：
Kim, Sung-Gon [1 ]
Ahm, Eun Ju [1 ]
Park, Tae-Ho [1 ]
机构：
[1] Korea Res Inst Chem Technol, Div Med Sci, Taejon 305600, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2007年 / 28卷 / 10期
关键词：
hydroxyamination; amino acid; amino alcohol; organocatalysis;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A direct regioselective alpha-hydroxyamination of alpha-branched aldehydes with nitrosobenzene using cis-5-benzylproline as catalyst has been developed for the preparation of alpha-hydroxyamino aldehydes possessing a quaternary carbon center. Such compounds are versatile building blocks for the synthesis of quaternary alpha-amino acids, 6-amino alcohols, and 1,2-diamines.
引用
收藏
页码：1665 / 1669
页数：5
相关论文
共 50 条
  • [1] Enantioselective organocatalytic formal allylation of α-branched aldehydes
    Rodrigo, Eduardo
    Morales, Sara
    Duce, Sara
    Garcia Ruano, Jose Luis
    Belen Cid, M.
    CHEMICAL COMMUNICATIONS, 2011, 47 (40) : 11267 - 11269
  • [2] Origin of Enantioselectivity in the Organocatalytic Reductive Amination of α-Branched Aldehydes
    Marcelli, Tommaso
    Hammar, Peter
    Himo, Fahmi
    ADVANCED SYNTHESIS & CATALYSIS, 2009, 351 (04) : 525 - 529
  • [3] Direct and enantioselective organocatalytic α-chlorination of aldehydes
    Brochu, MP
    Brown, SP
    MacMillan, DWC
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (13) : 4108 - 4109
  • [4] Direct organocatalytic asymmetric α-chlorination of aldehydes
    Halland, N
    Braunton, A
    Bachmann, S
    Marigo, M
    Jorgensen, KA
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (15) : 4790 - 4791
  • [5] The direct and enantioselective organocatalytic α-oxidation of aldehydes
    1600, American Chemical Society (125):
  • [6] Direct and Enantioselective Organocatalytic α-Chlorination of Aldehydes
    1600, American Chemical Society (126):
  • [7] Direct, organocatalytic α-sulfenylation of aldehydes and ketones
    Wang, W
    Li, H
    Wang, H
    Liao, LX
    TETRAHEDRON LETTERS, 2004, 45 (44) : 8229 - 8231
  • [8] The direct and enantioselective organocatalytic α-oxidation of aldehydes
    Brown, SP
    Brochu, MP
    Sinz, CJ
    MacMillan, DWC
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (36) : 10808 - 10809
  • [9] Direct Organocatalytic Asymmetric α-Chlorination of Aldehydes
    1600, American Chemical Society (126):
  • [10] Direct organocatalytic α-fluorination of aldehydes and ketones
    Enders, D
    Hüttl, MRM
    SYNLETT, 2005, (06) : 991 - 993
12345