Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo

被引：21
|
作者：
Yan, Zhen
Li, Ping
Akimoto, Takayuki
机构：
[1] Duke Univ, Med Ctr, Durham, NC USA
[2] Waseda Univ, Consolidated Res Inst Adv Sci & Med Care, Inst Biomed Engn, Tokyo, Japan
来源：
EXERCISE AND SPORT SCIENCES REVIEWS | 2007年 / 35卷 / 03期
关键词：
exercise; skeletal muscle adaptation; fiber-type switching; mitochondrial biogenesis; signal transduction; peroxisome proliferator-activated receptor gamma coactivator 1 alpha;
D O I：
10.1097/JES.0b013e3180a03169
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor gamma coactivator la gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1 alpha gene in skeletal muscle in vivo.
引用
收藏
页码：97 / 101
页数：5
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