The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

被引：19
|
作者：
Chen Xu'e [1 ]
Liu Zhixiang [1 ]
Yue Qing [1 ]
Liu Houjun [1 ]
Wu Yan [1 ]
Li Jiawen [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Dept Dermatol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China
来源：
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2007年 / 27卷 / 06期
关键词：
TNF-alpha; ICAM-1; lichen planus;
D O I：
10.1007/s11596-007-0632-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In order to investigate the role of TNF-alpha and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-alpha and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus.
引用
收藏
页码：739 / 741
页数：3
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