Solvent-Free Synthesis of Pyrrolo [2,1-α] Isoquinolines via One-Pot Four-Component Reaction

被引：2
|
作者：
Aminkhani, Ali [1 ]
Sharifi, Sina [2 ,3 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Khoy Branch, Khoy, Iran
[2] Harvard Med Sch, Massachusetts Eye & Ear, Dept Ophthalmol, Boston, MA 02115 USA
[3] Harvard Med Sch, Schepens Eye Res Inst, Boston, MA 02115 USA
来源：
LETTERS IN ORGANIC CHEMISTRY | 2022年 / 19卷 / 03期
关键词：
pyrrolo [2,1-a]isoquinoline; four-component reactions; isoquinoline; isocyanide; aromatic aldehydes; solvent-free synthesis; BRAIN DELIVERY; LAMELLARIN-D; DERIVATIVES; ALKALOIDS; CHEMISTRY; CHIRALITY; HYBRIDS; NMR;
D O I：
10.2174/1570178618666210805103552
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient four-component reaction to synthesize pyrrolo [2,1-a] isoquinolines from malononitrile, aromatic aldehydes, isoquinoline, and cyclohexyl isocyanide under solvent-free conditions is described. In a convenient, simple, and efficient one-pot procedure, the domino Knoevenagel-nucleophilic cycloaddition reaction affords excellent yields of products in less than 1 h.
引用
收藏
页码：244 / 249
页数：6
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