Structure activity relationship studies and pharmacological evaluation of 3,5-disubstituted thiophene-2-carboxylic acid derivatives:: Potent inhibitors of HCVNS5b polymerase and HCV subgenomic RNA replication.

被引：0

作者：

Poisson, C

Chan, L

Das, SK

Reddy, TJ

Pereira, OZ

Proulx, M

Halab, L

Courchesne, M

Roy, C

Yannopoulos, C

Siddiqui, A

Wang, WY

Nguyen-Ba, NP

Zhang, MQ

Bethell, R

L'Heureux, L

David, M

Bédard, J

Hamel, M

Bilimora, D

Nicolas, O

Morin, N

Asselin, P

Hamelin, B

Dong, K

Rioux, N

Richard, A

James, MNG

Wang, MT

Ng, KKS

Cherney, MM

机构：

[1] Shire BioChem Inc, Dept Med Chem, Laval, PQ H7V 4A7, Canada

[2] Shire BioChem Inc, Dept Virol, Laval, PQ H7V 4A7, Canada

[3] Shire BioChem Inc, Dept Pharmacol, Laval, PQ H7V 4A7, Canada

[4] Univ Alberta, Canadian Inst Hlth Res Grp Prot Structure & Funct, Dept BioChem, Edmonton, AB T6G 2M7, Canada

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 226卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

124-MEDI

引用

页码：U23 / U23

页数：1

共 7 条

[1] Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCVNS5B polymerase and HCV subgenomic RNA replication.: Part 1:: Sulfonamides
Chan, L
Das, SK
Reddy, TJ
Poisson, C
Proulx, M
Pereira, O
Courchesne, M
Roy, C
Wang, WY
Siddiqui, A
Yannopoulos, CG
Nguyen-Ba, N
Labrecque, D
Bethell, R
Hamel, M
Courtemanche-Asselin, P
L'Heureux, L
David, M
Nicolas, O
Brunette, S
Bilimoria, D
Bédard, J
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (03) : 793 - 796
[2] Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCVNS5B polymerase and HCV subgenomic RNA replication.: Part 2:: Tertiary amides
Chan, L
Pereira, O
Reddy, TJ
Das, SK
Poisson, C
Courchesne, M
Proulx, M
Siddiqui, A
Yannopoulos, CG
Nguyen-Ba, N
Roy, C
Nasturica, D
Moinet, C
Bethell, R
Hamel, M
L'Heureux, L
David, M
Nicolas, O
Courtemanche-Asselin, P
Brunette, S
Bilimoria, D
Bédard, J
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (03) : 797 - 800
[3] Structure-activity relationship (SAR) studies of quinoxalines as novel HCVNS5B RNA-dependent RNA polymerase inhibitors
Rong, Frank
Chow, Suetying
Yan, Shunqi
Larson, Gary
Hong, Zhi
Wu, Jim
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (06) : 1663 - 1666
[4] Discovery and SAR studies of 2,3,5-trisubstituted thiophene derivatives:: A novel class of HCVNS5b RNA dependent RNA polymerase inhibitors.
Reddy, TJ
Chan, L
Proulx, M
Das, SK
Pereira, OZ
Poisson, C
Nguyen-Ba, NP
Yannopoulos, C
Halab, L
Courchesne, M
Roy, C
Bethell, R
Zhang, MQ
Siddiqui, A
David, M
L'Heureux, L
Bédard, J
Nicolas, O
Hamelin, B
Dong, K
Rioux, N
Hamel, M
Morin, N
Asselin, P
Labelle, CC
Roberge, G
James, MNG
Wang, MT
Ng, KKS
Cherney, MM
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U4 - U4
[5] Design and synthesis of a novel series of 2-N-hydroxy-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid derivatives as HCV NS5B RNA-dependent RNA polymerase inhibitors
Deore, Ravindra Ramesh
Chen, Chien-Shu
Chang, Pei-Teh
Chern, Ji-Wang
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 239
[6] Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: Structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109
Hirashima, Shintaro
Suzuki, Takayoshi
Ishida, Tomio
Noji, Satoru
Yata, Shinji
Ando, Izuru
Komatsu, Masakazu
Ikeda, Satoru
Hashimoto, Hiromasa
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (15) : 4721 - 4736
[7] Synthesis, In Silico Designing, Microbiological Evaluation and Structure Activity Relationship of Novel Amide Derivatives of 1-(2,4-Dinitrophenyl)-2-(3-Methylbenzo[b]Thiophen-6-yl)-1H-Benzo[d]Imidazole-5-Carboxylic Acid
Hooda, Tanuj
Sharma, Sunil
Goyal, Naveen
POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (06) : 3361 - 3376

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