Sustained Efficacy and High Patient Satisfaction After Cheek Enhancement With a New Hyaluronic Acid Dermal Filler

Background: Increasing volume is an important part of facial rejuvenation since volume loss is common and typically age-related. HA(E) Volume is a moderately firm gel designed to be injected into the subcutaneous tissue for volume enhancement. Objective: To assess the efficacy, patient satisfaction, and safety of HA(E) Volume in patients with bilateral volume loss of the cheeks. Materials and Methods: This was a multi-center, six-month, open-label study. Subjects received HA(E) in the cheeks at baseline, and a touch-up injection was optional three weeks later. Global aesthetic improvement, cheek thickness (caliper measurements), changes in volume using three-dimensional (3-D) photo analysis, adverse events and injection site reactions were evaluated at each visit. Optimal correction was defined as results obtained three weeks after last injection. A subject satisfaction questionnaire was performed three weeks after the last injection. Results: Investigators evaluated the great majority of subjects as much or very much improved in terms of aesthetic improvement of their cheeks at week 3 and at months 3 and 6 (89.3%, 90.9%, and 76.4%, respectively). After six months, 65.8 percent of the correction achieved at week 3 (optimal correction) was maintained in terms of cheek thickness (caliper assessments), confirmed by 677 percent of the volume maintained based on 3-D volume analyses. The majority of subjects (92.1%) were satisfied or very satisfied with their aesthetic outcome. A good tolerability profile was observed. Conclusions: Treatment with HA(E) Volume in cheeks led to good aesthetic improvement, sustained results confirmed by caliper and 3-D volume assessments, and high subject satisfaction.