Mechanisms Involved in Placebo and Nocebo Responses and Implications for Drug Trials

被引：88

作者：

Rief, W. ^{[1
]}

Bingel, U. ^{[2
]}

Schedlowski, M. ^{[3
]}

Enck, P. ^{[4
]}

机构：

[1] Univ Marburg, Div Clin Psychol, Marburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Hamburg, Germany

[3] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Psychol & Behav Immunobiol, Essen, Germany

[4] Univ Hosp Tuebingen, Dept Internal Med 6, Tubingen, Germany

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2011年 / 90卷 / 05期

关键词：

RANDOMIZED CONTROLLED-TRIAL; DISEASE; METAANALYSIS; ACUPUNCTURE; EXPECTATION;

D O I：

10.1038/clpt.2011.204

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drug trials often compare active drugs with inert placebos under double-blind conditions. This standard design is increasingly being questioned in light of recent progress in understanding the mechanisms behind the placebo response.(1,2) The growing knowledge of the neurobiology of placebo is forcing us to reconsider the significance of the placebo in clinical practice, with consequent profound implications for the design of clinical trials.

引用

页码：722 / 726

页数：5

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