Preparation and Evaluation of Once a Day Extended Release Tablet of Propranolol Hydrochloride

The objective of the present investigation was to develop once a day extended release tablet formulation of propranolol hydrochloride employing hydroxypropyl methylcellulose (HPMC). Different batches of propranolol hydrochloride extended release tablets were prepared by using different grades of HPMC (Methocel K4M, Methocel K15M and Methocel K100M) in order to get desired release profile. The optimized batch criteria were selected considering USP limits of dissolution study for extended release propranolol hydrochloride tablets. The physical parameters (crushing strength and friability) of all formulated batches were within acceptable limits. The results of dissolution study indicated that as amount of higher viscosity grade HPMC in tablet composition increases there is retardation of drug release. The optimized batch S8 containing 30% w/w of Methocel K100M showed highest similarity factor (f(2)) value of 73.8. The mean dissolution time of batch S8 was 7.27 h. The kinetics of drug release was best explained by Korsmeyer and Peppas model. The optimized batch passed stability study carried out at 25 +/- 2 degrees C and 60 +/- 5%RH for 6 months.