The developmental genetics of congenital heart disease

被引：583
|
作者：
Bruneau, Benoit G. [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA
来源：
NATURE | 2008年 / 451卷 / 7181期
关键词：
D O I：
10.1038/nature06801
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Congenital heart disease is the leading cause of infant morbidity in the Western world, but only in the past ten years has its aetiology been understood. Recent studies have uncovered the genetic basis for some common forms of the disease and provide new insight into how the heart develops and how dysregulation of heart development leads to disease.
引用
收藏
页码：943 / 948
页数：6
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