Detection of Bacillus Galmette-Guerin (Mycobacterium bovis BCG) DNA in Urine and Blood Specimens after Intravesical Immunotherapy for Bladder Carcinoma

被引：12
|
作者：
Siatelis, Argyrios [2 ]
Houhoula, Dimitra P. [1 ]
Papaparaskevas, Joseph [1 ]
Delakas, Dimitrios [2 ]
Tsakris, Athanassios [1 ]
机构：
[1] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece
[2] Asclepe Gen Hosp, Dept Urol, Voula 16673, Greece
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2011年 / 49卷 / 04期
关键词：
CALMETTE-GUERIN; CANCER; TUBERCULOSIS; PCR; QUANTIFICATION; COMPLICATIONS; DIAGNOSIS; DISEASES; THERAPY;
D O I：
10.1128/JCM.01595-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A real-time PCR targeting IS6110 was employed for the detection of Mycobacterium tuberculosis DNA in specimens collected from 10 patients treated with intravesical M. bovis bacillus Galmette-Guerin (BCG) immunotherapy for bladder malignancy. BCG DNA was detected in all urine specimens taken 24 h after the instillations, as well as in 24% of the specimens collected 7 days after the instillations; it was also detected in a single specimen taken 6 weeks after the last instillation. BCG DNA was detected in 8.3% of the blood specimens taken 1 day after instillation, and its amplification was associated with cases of self-limiting fever. These findings give indications that this real-time PCR is helpful to recognize BCG bacteremic cases, which may lead to mycobacterial infection.
引用
收藏
页码：1206 / 1208
页数：3
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