FULLY AUTOMATED CAROTID PLAQUE SEGMENTATION IN COMBINED CONTRAST-ENHANCED AND B-MODE ULTRASOUND

Carotid plaque segmentation in B-mode ultrasound (BMUS) and contrast-enhanced ultrasound (CEUS) is crucial to the assessment of plaque morphology and composition, which are linked to plaque vulnerability. Segmentation in BMUS is challenging because of noise, artifacts and echo-lucent plaques. CEUS allows better delineation of the lumen but contains artifacts and lacks tissue information. We describe a method that exploits the combined information from simultaneously acquired BMUS and CEUS images. Our method consists of non-rigid motion estimation, vessel detection, lumen-intima segmentation and media-adventitia segmentation. The evaluation was performed in training (n = 20 carotids) and test (n = 28) data sets by comparison with manually obtained ground truth. The average root-mean-square errors in the training and test data sets were comparable for media-adventitia (411 +/- 224 and 393 +/- 239 mm) and for lumen-intima (362 +/- 192 and 388 +/- 200 mm), and were comparable to inter-observer variability. To the best of our knowledge, this is the first method to perform fully automatic carotid plaque segmentation using combined BMUS and CEUS. (E-mail: j.bosch@erasmusmc.nl) (C) 2015 World Federation for Ultrasound in Medicine & Biology.