Pd-Catalyzed Cascade Heck-type Annulation and Carbonylation to β-Oxindolysulfoximidoyl Amides at Room Temperature

被引：6

作者：

Liu, Huahua ^{[1
]}

Xiong, Yuping ^{[1
]}

Chen, Zhiyuan ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Funct Small Organ Mol, Ziyang Rd 99, Nanchang 330022, Jiangxi, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Palladium Catalysis; Heck reaction; Carbonylation; Sulfoximine; oxindole; DRUG DISCOVERY; SULFOXIMINES; REACTIVITY; BOND;

D O I：

10.1002/ajoc.202100451

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient intramolecular Heck annulation and trapping of the resulting cyclic alpha-oxindolylpalladium species by CO (1 atm) and NH-sulfoximine in a cascade protocol at room temperature was described, which offering 3,3-disubstituted beta-indoly sulfoximidoyl amides in mostly excellent yields under very gentle reaction conditions.

引用

页码：2351 / 2354

页数：4

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