Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults

被引:4
|
作者
Spencer, Sarah [1 ]
Chung, Jessie R. [1 ]
Belongia, Edward A. [2 ]
Sundaram, Maria [2 ]
Meece, Jennifer [2 ]
Coleman, Laura A. [2 ,3 ]
Zimmerman, Richard K. [4 ]
Nowalk, Mary Patricia [4 ]
Geffel, Krissy Moehling [4 ]
Ross, Ted [4 ,5 ]
Carter, Chalise E. [4 ,5 ]
Shay, David [1 ]
Levine, Min [1 ]
Liepkalns, Justine [1 ,6 ]
Kim, Jin Hyang [1 ,7 ]
Sambhara, Suryaprakash [1 ]
Thompson, Mark G. [1 ]
Flannery, Brendan [1 ]
机构
[1] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA
[2] Novartis Inst Biomed Res, Translat Med, Basel, Switzerland
[3] Marshfield Clin Res Inst, Ctr Clin Epidemiol & Populat Hlth, Marshfield, WI USA
[4] Univ Georgia, Dept Infect Dis, Ctr Vaccines & Immunol, Athens, GA 30602 USA
[5] Univ Pittsburgh, Sch Med, Dept Family Med, Pittsburgh, PA USA
[6] Univ Washington, Dept Biol, Seattle, WA 98195 USA
[7] Bristol Myers Squibb, Translat Med, Princeton, NJ USA
基金
美国国家卫生研究院;
关键词
influenza; serologic response; vaccine; SEASONAL INFLUENZA; ANTIBODY-RESPONSE; EFFICACY; TITERS;
D O I
10.1111/irv.12933
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50-80 with and without type 2 diabetes mellitus. Serologic response to influenza vaccination was similar in both groups: greater fold-increases in antibody titer occurred among participants with lower pre-vaccination antibody titers. Waning of antibody titers was not influenced by diabetes status.
引用
收藏
页码:562 / 567
页数:6
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