AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

被引：132

作者：

Lux, Francois ^{[1
,2
]}

Vu Long Tran ^{[2
,3
]}

Thomas, Eloise ^{[2
]}

Dufort, Sandrine ^{[1
]}

Rossetti, Fabien ^{[2
]}

Martini, Matteo ^{[2
]}

Truillet, Charles ^{[4
]}

Doussineau, Tristan ^{[1
]}

Bort, Guillaume ^{[2
]}

Denat, Franck ^{[5
]}

Boschetti, Frederic ^{[6
]}

Angelovski, Goran ^{[7
]}

Detappe, Alexandre ^{[8
]}

Cremillieux, Yannick ^{[9
]}

Mignet, Nathalie ^{[10
,11
,12
,13
]}

Bich-Thuy Doan ^{[10
,11
,12
,13
]}

Larrat, Benoit ^{[14
,15
]}

Meriaux, Sebastien ^{[14
,15
]}

Barbier, Emmanuel ^{[16
]}

Roux, Stephane ^{[17
]}

Fries, Peter ^{[18
]}

Mueller, Andreas ^{[18
]}

Abadjian, Marie-Caline ^{[19
,20
]}

Anderson, Carolyn ^{[19
,20
]}

Canet-Soulas, Emmanuelle ^{[21
]}

Bouziotis, Penelope ^{[22
]}

Barberi-Heyob, Muriel ^{[23
]}

Frochot, Celine ^{[24
]}

Verryy, Camille ^{[25
]}

Balosso, Jacques ^{[25
]}

Evans, Michael ^{[26
]}

Sidi-Boumedine, Jacqueline ^{[27
]}

Janier, Marc ^{[27
,28
]}

Butterworth, Karl ^{[29
]}

McMahon, Stephen ^{[29
]}

Prise, Kevin ^{[29
]}

Aloy, Marie-Therese ^{[30
,31
]}

Ardail, Dominique ^{[30
,31
]}

Rodriguez-Lafrasse, Claire ^{[30
,31
]}

Porcel, Erika ^{[32
]}

Lacombe, Sandrine ^{[32
]}

Berbeco, Ross ^{[8
]}

Allouch, Awatef ^{[33
,34
,35
,36
]}

Perfettini, Jean-Luc ^{[33
,34
,35
,36
]}

Chargari, Cyrus ^{[37
,38
,39
,40
]}

Deutsch, Eric ^{[39
,40
]}

Le Duc, Geraldine ^{[1
]}

Tillement, Olivier ^{[1
,2
]}

机构：

[1] NH TherAguix SAS, Villeurbanne, France

[2] Univ Claude Bernard Lyon 1, Univ Lyon, CNRS, Inst Lumiere Matiere, Lyon, France

[3] Nano H SAS, St Quentin Fallavier, France

[4] Univ Paris Saclay, Univ Paris Sud, Serv Hosp Freder Joliot, INSERM,CEA,CNRS,Imagerie Mol Vivo, Orsay, France

[5] Univ Bourgogne, Inst Chim Mol, Dijon, France

[6] CheMatech, Fac Sci Mirande, Dijon, France

[7] Max Planck Inst Biol Cybernet, MR Neuroimaging Agents, Tubingen, Germany

[8] Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA

[9] Univ Bordeaux, CNRS, Ctr Resonance Magnet Syst Biol, UMR, Bordeaux, France

[10] PSL Res Univ, Chim ParisTech, UTCBS, Paris, France

[11] CNRS, UTCBS, UMR, Paris, France

[12] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[13] INSERM, U1022, UTCBS, Paris, France

[14] CEA Saclay, NeuroSpin, Gif Sur Yvette, France

[15] Univ Paris Saclay, Orsay, France

[16] Univ Grenoble Alpes, Grenoble Inst Neurosci, INSERM, Grenoble, France

[17] Univ Bourgogne Franche Comte, CNRS, UMR 6213, Inst UTINAM, Besancon, France

[18] Saarland Univ, Med Ctr, Clin Diagnost & Intervent Radiol, Homburg, Germany

[19] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[20] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA

[21] Univ Lyon 1, INSA Lyon, Univ Lyon, INSERM,CarMeN Lab,INRA,U1397,U1060, Oullins, France

[22] Natl Ctr Sci Res Demokritos, Inst Nucl & Radiol Sci & Technol Energy & Safety, Athens, Greece

[23] Univ Lorraine, CNRS, CRAN, Nancy, France

[24] Univ Lorraine, CNRS, Lab React & Genie Proc, UMR, Nancy, France

[25] CHU Grenoble, Radiotherapy Dept, Grenoble 9, France

[26] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[27] Univ Claude Bernard Lyon 1, Univ Lyon, Villeurbanne, France

[28] Hop Edouard Herriot, Plateforme Imthernat, Hosp Civils Lyon, Lyon, France

[29] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast BT9 7AE, Antrim, North Ireland

[30] Univ Lyon 1, Fac Med Lyon Sud, Lab Radiobiol Cellulaire & Mol, IPNL,PRISME, Pierre Benite, France

[31] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Pierre Benite, France

[32] Univ Paris Sud, Univ Paris Saclay, CNRS, ISMO,UMR, Orsay, France

[33] Gustave Roussy, Cell Death & Aging Team, Rue Edouard Vaillant, Villejuif, France

[34] Gustave Roussy, INSERM, Lab Mol Radiotherapy, Rue Edouard Vaillant, Villejuif, France

[35] Gustave Roussy, Rue Edouard Vaillant, Villejuif, France

[36] Univ Paris Sud Paris, Rue Edouard Vaillant, Villejuif, France

[37] French Mil Hlth Acad, Ecole Val de Grace, Paris, France

[38] Inst Rech Biomed Armees, Bretigny Sur Orge, France

[39] Gustave Roussy, Radiotherapy Dept, Villejuif, France

[40] Gustave Roussy Canc Campus, Brachytherapy Unit, Villejuif, France

来源：

BRITISH JOURNAL OF RADIOLOGY | 2018年 / 92卷 / 1093期

关键词：

SMALL RIGID PLATFORMS; RADIATION-THERAPY; GOLD NANOPARTICLES; PHOTODYNAMIC THERAPY; CONTRAST AGENTS; PHASE-I; FUNCTIONALIZATION; PARTICLES; MRI; RADIOSENSITIZATION;

D O I：

10.1259/bjr.20180365

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

AGuIX (R) are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations in vitro and in vivo on a large number of cancer types (brain, lung, melanoma, head and neck ...). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.

引用

页数：19

共 30 条

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MEDICAL PHYSICS, 2015, 42 (06) : 3566 - 3566
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