Early detection of liver cancer based on bioluminescence tomography

被引：17

作者：

Ma, Xibo ^{[1
]}

Tian, Jie ^{[1
]}

Qin, Chenghu ^{[1
]}

Yang, Xin ^{[1
]}

Zhang, Bo ^{[1
]}

Xue, Zhenwen ^{[1
]}

Zhang, Xing ^{[1
]}

Han, Dong ^{[1
]}

Dong, Di ^{[1
]}

Liu, Xueyan ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Automat, Med Imaging Proc Grp, Beijing 100190, Peoples R China

来源：

APPLIED OPTICS | 2011年 / 50卷 / 10期

基金：

中国国家自然科学基金;

关键词：

PROTEIN-PROTEIN INTERACTIONS; IN-VIVO; HEPATOCELLULAR-CARCINOMA; LIVING ANIMALS; MOUSE MODEL; INHIBITION; LUCIFERASE; LIGHT; COMPLEMENTATION; METASTASIS;

D O I：

10.1364/AO.50.001389

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

As a new modality of molecular imaging, bioluminescence imaging has been widely used in tumor detection and drug evaluation. However, BLI cannot present the depth of information for internal diseases such as a liver tumor in situ or a lung tumor in situ. In this paper, we describe a bioluminescence tomography (BLT) method based on the bioluminescent intensity attenuation calibration and applied it to the early detection of liver cancer in situ. In comparison with BLT without calibration, this method could improve the reconstruction accuracy by more than 10%. In comparison with micro-computed tomography and other traditional imaging modalities, this method can detect a liver tumor at a very early stage and provide reliable location information. (C) 2011 Optical Society of America

引用

页码：1389 / 1395

页数：7

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